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Aberrant social behavior is a hallmark of various psychiatric and neurological disorders, including autism, schizophrenia, and social anxiety disorder. We tailor apparatus to assess social functioning in animal models, facilitating drug discovery and the exploration of neural mechanisms underlying social behavior.
Modified from the conventional three-chamber social apparatus, the linear social chamber (item # 05010) composes one center box with two small removable lateral chambers to facilitate in vivo imaging and electrophysiology recording during social behaviors.
Contact us to customize the dimensions at info@behaviorsync.com
This linear social apparatus removed the dividing walls of the conventional three-chamber social device to facilitate in vivo imaging and electrophysiology of animals during social behavior. Two detachable chambers (target chambers) were placed at both ends of the apparatus, separated by 1 cm spaced thin metal wires, allowing mice to interact with stimuli. It’s advisable for both the test animals and the social stimulus animals prior to the social interaction task. Our removal later chambers enable simultaneous habituation of both test and social stimulus animals without any physical interactions.
We provide extra sets of lateral chambers to streamline the cleaning and drying process during experiments, reducing your workload.
Time the test animal spent in the interacting zones, social zone, object zone, and the middle zone can be collected to evaluate the test animal’s sociability and social novelty preference.
Dimensions for Animal Model: Mouse
Dimensions for Animal Model: Rat
Pattern decorrelation in the mouse medial prefrontal cortex enables social preference and requires MeCP2
Xu et al., Nature Communications, 13, 3899 (2022)
“Each test consisted of three 10-minute sessions, which were conducted following 10-minute habituation in the center. At the beginning of each session, the testing mouse was placed in the center of the open box and allowed to explore freely. In session 1 (S1), an age- and weight-matched same-sex conspecific (the first social stimulus, M1) and a centrifuge tube (object, O) were separately placed in the end chambers randomly. In session 2 (S2), the positions of those two stimuli were switched, which was designed to diminish the spatial influence in stimulus-induced neural activities. A healthy mouse prefers social over inanimate stimuli. In session 3 (S3), a new age- and weight-matched same-sex conspecific (new social stimulus, M2) replaced the object in the lateral chamber to evaluate social novelty preference; wild-type mice spent more time with a new conspecific than with a familiar one. The time spent involved in social interaction, object interaction, social zone, object zone, and middle zone were measured.”
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